Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathiesReport as inadecuate




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Reference: Parkkinen, L, Fairfoul, G, McGuire, LI et al., (2016). Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies. Annals of Clinical and Translational Neurology, 3 (10), 812-818.Citable link to this page:

 

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

Abstract: We have developed a novel real-time quaking-induced conversion RT-QuICbased assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson’s disease patients. This assay can detect alpha-synuclein aggregation in Dementia with Lewy bodies and Parkinson’s disease cerebrospinal fluid with sensitivities of 92% and 95%, respectively, and with an overall specificity of 100% when compared to Alzheimer and control cerebrospinal fluid. Patients with neuropathologically confirmed tauopathies (progressive supranuclear palsy; corticobasal degeneration) gave negative results. These results suggest that RT-QuiC analysis of cerebrospinal fluid is potentially useful for the early clinical assessment of patients with alpha-synucleinopathies.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:2016-07-12 Funder: Scottish Government’s Chief Scientists Office   Funder: Michael J Fox foundation   Funder: Department of Health   Funder: Scottish Home Office Department of Health   Funder: Medical Research Council   Notes:© 2016 The Authors. Annals of Clinical and Translational Neurologypublished by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Bibliographic Details

Publisher: Wiley

Publisher Website: http://www.wiley.com/

Journal: Annals of Clinical and Translational Neurologysee more from them

Publication Website: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2328-9503

Volume: 3

Issue: 10

Extent: 812-818

Issue Date: 2016-08

pages:812-818Identifiers

Doi: https://doi.org/10.1002/acn3.338

Issn: 2328-9503

Uuid: uuid:46dc2a4a-9b54-4058-bd38-52baca481aea

Urn: uri:46dc2a4a-9b54-4058-bd38-52baca481aea

Pubs-id: pubs:648554 Item Description

Type: journal-article;

Version: Publisher's version

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Author: Parkkinen, L - Oxford, MSD, Clinical Neurosciences - - - Fairfoul, G - - - McGuire, LI - - - Pal, S - - - Ironside, JW - - - Neum

Source: https://ora.ox.ac.uk/objects/uuid:46dc2a4a-9b54-4058-bd38-52baca481aea



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