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Reference: McLean, F, Boel, ME, McGready, R et al., (2016). Antibody responses to Plasmodium falciparum and Plasmodium vivax blood-stage and sporozoite antigens in the postpartum period. Scientific Reports, 6, Article: 32159.Citable link to this page:

 

Antibody responses to Plasmodium falciparum and Plasmodium vivax blood-stage and sporozoite antigens in the postpartum period

Abstract: During pregnancy a variety of immunological changes occur to accommodate the fetus. It is unknown whether these changes continue to affect humoral immunity postpartum or how quickly they resolve. IgG levels were measured to P. falciparum and P. vivax antigens in 201 postpartum and 201 controls over 12 weeks. Linear mixed-effects models assessed antibody maintenance over time and the effect of microscopically confirmed Plasmodium spp. infection on antibody levels, and whether this was different in postpartum women compared with control women. Postpartum women had reduced Plasmodium spp. antibody levels compared to controls at baseline. Over 12 weeks, mean antibody levels in postpartum women increased to levels observed in control women. Microscopically confirmed P. falciparum and P. vivax infections during follow-up were associated with an increase in species-specific antibodies with similar magnitudes of boosting observed in postpartum and control women. Antibodies specific for pregnancy-associated, VAR2CSA-expressing parasites did not rapidly decline postpartum and did not boost in response to infection in either postpartum or control women. After pregnancy, levels of malaria-specific antibodies were reduced, but recovered to levels seen in control women. There was no evidence of an impaired ability to mount a boosting response in postpartum women.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:03 August 2016Notes:This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Bibliographic Details

Publisher: Nature Publishing Group

Publisher Website: http://www.nature.com/

Journal: Scientific Reportssee more from them

Publication Website: http://www.nature.com/srep

Volume: 6

Extent: Article: 32159

Issue Date: 2016

pages:Article: 32159Identifiers

Issn: 2045-2322

Doi: https://doi.org/10.1038/srep32159

Uuid: 155819c1-c58d-4171-b95e-28aecdfd5edf

Urn: uri:155819c1-c58d-4171-b95e-28aecdfd5edf

Pubs-id: pubs:637441 Item Description

Type: journal-article;

Version: Publisher's version

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Author: McLean, F - - - Boel, ME - - - McGready, R - Oxford, MSD, NDM, Tropical Medicine - - - Ataide, R - - - Drew, D - - - Tsuboi, T -

Source: https://ora.ox.ac.uk/objects/uuid:155819c1-c58d-4171-b95e-28aecdfd5edf



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