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Reference: Balmus, G, Barros, AC, Wijnhoven, PWG et al., (2016). Synthetic lethality between PAXX and XLF in mammalian development. Genes and Development, 30 (19), 2152-2157.Citable link to this page:

 

Synthetic lethality between PAXX and XLF in mammalian development

Abstract: PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated Paxx-deficient mice. Like Xlf−/− mice, Paxx−/− mice are viable, grow normally, and are fertile but show mild radiosensitivity. Strikingly, while Paxx loss is epistatic with Ku80, Lig4, and Atm deficiency, Paxx/Xlf double-knockout mice display embryonic lethality associated with genomic instability, cell death in the central nervous system, and an almost complete block in lymphogenesis, phenotypes that closely resemble those of Xrcc4−/− and Lig4−/− mice. Thus, combined loss of Paxx and Xlf is synthetic-lethal in mammals.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:2016-09-21 Funder: Cancer Research UK   Funder: European Research Council   Funder: Wellcome Trust   Notes:© 2016 Balmus et al.; Published by Cold Spring Harbor Laboratory Press. This article, published in Genes and Development, is available under a Creative Commons License (Attribution 4.0 International).

Bibliographic Details

Publisher: Cold Spring Harbor Laboratory Press

Publisher Website: http://www.cshlpress.com/

Journal: Genes and Developmentsee more from them

Publication Website: http://www.genesdev.org/

Volume: 30

Issue: 19

Extent: 2152-2157

Issue Date: 2016-10-01

pages:2152-2157Identifiers

Doi: https://doi.org/10.1101/gad.290510.116

Issn: 0890-9369

Eissn: 1549-5477

Uuid: uuid:15d398fe-f1a4-43d1-9af4-3c66102449fd

Urn: uri:15d398fe-f1a4-43d1-9af4-3c66102449fd

Pubs-id: pubs:656512 Item Description

Type: journal-article;

Version: Publisher's versionKeywords: ATM development NHEJ PAXX synthetic lethality XLF

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Author: Balmus, G - - - Barros, AC - - - Wijnhoven, PWG - - - Blackford, A - Oxford, MSD, Oncology, CRUK-MRC Ox Inst for Radiation Oncolo

Source: https://ora.ox.ac.uk/objects/uuid:15d398fe-f1a4-43d1-9af4-3c66102449fd



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