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Reference: Adekunle, AI, Pinkevych, M, McGready, R et al., (2015). Modeling the Dynamics of Plasmodium vivax Infection and Hypnozoite Reactivation In Vivo. PLoS Neglected Tropical Diseases.Citable link to this page:

 

Modeling the Dynamics of Plasmodium vivax Infection and Hypnozoite Reactivation In Vivo

Abstract: © 2015 Adekunle et al.The dynamics of Plasmodium vivax infection is characterized by reactivation of hypnozoites at varying time intervals. The relative contribution of new P. vivax infection and reactivation of dormant liver stage hypnozoites to initiation of blood stage infection is unclear. In this study, we investigate the contribution of new inoculations of P. vivax sporozoites to primary infection versus reactivation of hypnozoites by modeling the dynamics of P. vivax infection in Thailand in patients receiving treatment for either blood stage infection alone (chloroquine), or the blood and liver stages of infection (chloroquine + primaquine). In addition, we also analysed rates of infection in a study in Papua New Guinea (PNG) where patients were treated with either artesunate, or artesunate + primaquine. Our results show that up to 96% of the P. vivax infection is due to hypnozoite reactivation in individuals living in endemic areas in Thailand. Similar analysis revealed the around 70% of infections in the PNG cohort were due to hypnozoite reactivation. We show how the age of the cohort, primaquine drug failure, and seasonality may affect estimates of the ratio of primary P. vivax infection to hypnozoite reactivation. Modeling of P. vivax primary infection and hypnozoite reactivation provides important insights into infection dynamics, and suggests that 90–96% of blood stage infections arise from hypnozoite reactivation. Major differences in infection kinetics between Thailand and PNG suggest the likelihood of drug failure in PNG.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's version Funder: /Wellcome Trust   Notes:© 2015 Adekunle et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Bibliographic Details

Publisher: PLoS

Publisher Website: https://www.plos.org/

Journal: PLoS Neglected Tropical Diseasessee more from them

Publication Website: http://journals.plos.org/plosntds/

Volume: 9

Extent: e0003595

Issue Date: March 2015Identifiers

Doi: https://doi.org/10.1371/journal.pntd.0003595

Issn: 1935-2735

Issn: 1935-2735

Uuid: 78626775-73e3-4bb5-9d98-fbee0fc0e196

Urn: uri:78626775-73e3-4bb5-9d98-fbee0fc0e196

Pubs-id: pubs:514969 Item Description

Type: journal-article;

Language: eng

Version: Publisher's versionKeywords: Aged Animals Antimalarials Artemisinins Chloroquine Female Humans Liver Malaria, Vivax Male Models, Biological Papua New Guinea Plasmodium vivax Primaquine Sporozoites Thailand Torpor Journal Article

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Author: Adekunle, AI - - - Pinkevych, M - - - McGready, R - - - Luxemburger, C - - - White, Lisa - Oxford, MSD, NDM, Tropical Medicine Wa

Source: https://ora.ox.ac.uk/objects/uuid:78626775-73e3-4bb5-9d98-fbee0fc0e196



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