Phosphodiester content measured in human liver by in vivo 31 P MR spectroscopy at 7 tesla.Report as inadecuate




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Reference: Purvis, LA, Clarke, WT, Valkovič, L et al., (2017). Phosphodiester content measured in human liver by in vivo (31) P MR spectroscopy at 7 tesla. Magnetic Resonance in Medicine.Citable link to this page:

 

Phosphodiester content measured in human liver by in vivo (31) P MR spectroscopy at 7 tesla.

Abstract: PurposePhosphorus (31P) metabolites are emerging liver disease biomarkers. Of particular interest are phosphomonoester and phosphodiester (PDE) “peaks” that comprise multiple overlapping resonances in 31P spectra. This study investigates the effect of improved spectral resolution at 7 Tesla (T) on quantifying hepatic metabolites in cirrhosis.MethodsFive volunteers were scanned to determine metabolite T1s. Ten volunteers and 11 patients with liver cirrhosis were scanned at 7T. Liver spectra were acquired in 28 min using a 16-channel 31P array and 3D chemical shift imaging. Concentrations were calculated using γ-adenosine-triphosphate (γ-ATP) = 2.65 mmol/L wet tissue.ResultsT1 means ± standard deviations: phosphatidylcholine 1.05 ± 0.28 s, nicotinamide-adenine-dinucleotide (NADþ) 2.0 ± 1.0 s, uridine-diphosphoglucose (UDPG) 3.3 ± 1.4 s. Concentrations in healthy volunteers: a-ATP 2.74 ± 0.11 mmol/L wet tissue, inorganic phosphate 2.23 ± 0.20 mmol/L wet tissue, glycerophosphocholine 2.34 ± 0.46 mmol/L wet tissue, glycerophosphoethanolamine 1.50 ± 0.28mmol/L wet tissue, phosphocholine 1.06 ± 0.16 mmol/L wet tissue, phosphoethanolamine 0.77 ± 0.14 mmol/L wet tissue, NADþ 2.37 ± 0.14 mmol/L wet tissue, UDPG 2.00 ± 0.22 mmol/L wet tissue, phosphatidylcholine 1.38 ± 0.31 mmol/L wet tissue. Inorganic phosphate and phosphatidylcholine concentrations were significantly lower in patients; glycerophosphoethanolamine concentrations were significantly higher (P



Author: Purvis, LA - facultyOxford, MSD, RDM, RDM Cardiovascular Medicine - - - Clarke, WT - facultyOxford, MSD, Clinical Neurosciences -

Source: https://ora.ox.ac.uk/objects/uuid:c51d3b2a-c4b4-4750-9aff-492f026a347a



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