OCT angiography-based detection and quantification of the neovascular network in exudative AMDReport as inadecuate




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Reference: Lindner, M, Fang, PP, Steinberg, JS et al., (2016). OCT angiography-based detection and quantification of the neovascular network in exudative AMD. Investigative Ophthalmology & Visual Science, 57 (14), 6342-6348.Citable link to this page:

 

OCT angiography-based detection and quantification of the neovascular network in exudative AMD

Abstract: Purpose: To investigate the potential of optical coherence tomography (OCT) angiography to detect and quantify the neovascular network in exudative AMD. Methods: Treatment-naïve eyes that were diagnosed with exudative AMD were prospectively examined by OCT angiography (OCT-A). The extent of the neovascular network was measured by three independent readers. Interclass-correlation coefficient and area overlap coefficients (OC) were calculated to assess locally precise agreement between measurements. As a reference for interreader agreement, the extent of the neovascular network was further measured on fluorescein angiography (FA) images. Results: A total of 31 eyes (27 patients, mean age 82.5 years, 15 female) were included in the study. Neovascularization subtype was classified as type I in 5, type II in 11, type III in 9, and mixed in 6 eyes, respectively. Interreader agreement for measurements of the neovascular network was 0.884 for OCT-A and 0.636 for FA. Overlap coefficient was 0.705 (interquartile [IQR]: 0.450-0.76) for OCT-A and 0.704 (IQR: 0.673-0.750) for FA, respectively. Area agreement was weaker in type III and mixed lesions. Conclusions: Optical coherence tomography angiography-based measurements of the new vessel complex in neovascular AMD are feasible with interreader agreement comparable with the values obtained for FA. The results underscore the potential of OCT-A as a noninvasive diagnostic tool in neovascular AMD. Yet, further studies will be required to reveal the origin of poor agreement observed in single eyes and to advance OCT-A toward dependable use (e.g., in a reading center context).

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:17 October 2016Notes:This work is licensed under a Creative Commons Attribution 4.0 International License.

Bibliographic Details

Publisher: Association for Research in Vision and Ophthalmology

Publisher Website: http://www.arvo.org/

Journal: Investigative Ophthalmology & Visual Sciencesee more from them

Publication Website: http://iovs.arvojournals.org/

Volume: 57

Issue: 14

Extent: 6342-6348

Issue Date: 01 November 2016

pages:6342-6348Identifiers

Doi: https://doi.org/10.1167/iovs.16-19741

Issn: 0146-0404

Eissn: 1552-5783

Uuid: uuid:e33bca69-a3a8-4622-8a7b-5b7411125a91

Urn: uri:e33bca69-a3a8-4622-8a7b-5b7411125a91

Pubs-id: pubs:690082 Item Description

Type: journal-article;

Language: eng

Version: Publisher's versionKeywords: optical coherence tomography angiography fluorescein angiography age-related macular degeneration choroidal neovascularization full spectrum amplitude decorrelation

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Author: Lindner, M - Oxford, MSD, Clinical Neurosciences St Cross College fundingUniversity of Bonn grantNumberO-137.0020 - - - Fang, PP

Source: https://ora.ox.ac.uk/objects/uuid:e33bca69-a3a8-4622-8a7b-5b7411125a91



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