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Reference: Barnsley, LC, Carugo, D, Aron, M et al., (2017). Understanding the dynamics of superparamagnetic particles under the influence of high field gradient arrays. Physics in Medicine and Biology, 62 (6), 2333.Citable link to this page:

 

Understanding the dynamics of superparamagnetic particles under the influence of high field gradient arrays

Abstract: The aim of this study was to characterize the behaviour of superparamagnetic particles in magnetic drug targeting (MDT) schemes. A 3- dimensional mathematical model was developed, based on the analytical derivation of the trajectory of a magnetized particle suspended inside a fluid channel carrying laminar flow and in the vicinity of an external source of magnetic force. Semianalytical expressions to quantify the proportion of captured particles, and their relative accumulation (concentration) as a function of distance along the wall of the channel were also derived. These were expressed in terms of a non-dimensional ratio of the relevant physical and physiological parameters corresponding to a given MDT protocol. The ability of the analytical model to assess magnetic targeting schemes was tested against numerical simulations of particle trajectories. The semi-analytical expressions were found to provide good first-order approximations for the performance of MDT systems in which the magnetic force is relatively constant over a large spatial range. The numerical model was then used to test the suitability of a range of different designs of permanent magnet assemblies for MDT. The results indicated that magnetic arrays that emit a strong magnetic force that varies rapidly over a confined spatial range are the most suitable for concentrating magnetic particles in a localized region. By comparison, commonly used magnet geometries such as button magnets and linear Halbach arrays result in distributions of accumulated particles that are less efficient for delivery. The trajectories predicted by the numerical model were verified experimentally by acoustically focusing magnetic microbeads flowing in a glass capillary channel, and optically tracking their path past a high field gradient Halbach array.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:2017-01-23 Funder: Engineering and Physical Sciences Research Council   Notes:¬© 2017 Institute of Physics and Engineering in Medicine. Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence.

Bibliographic Details

Publisher: IOP Publishing

Publisher Website: http://www.iop.org/

Journal: Physics in Medicine and Biologysee more from them

Publication Website: http://iopscience.iop.org/1475-7516

Volume: 62

Issue: 6

Extent: 2333

Issue Date: 2017-02-24

pages:2333Identifiers

Issn: 0031-9155

Eissn: 1361-6560

Uuid: uuid:e4c56b38-530e-4cb4-bd20-d3a5f6a047bc

Urn: uri:e4c56b38-530e-4cb4-bd20-d3a5f6a047bc

Pubs-id: pubs:673329

Doi: https://doi.org/10.1088/1361-6560/aa5d46 Item Description

Type: journal-article;

Version: Publisher's versionKeywords: Magnetic drug targeting Halbach array Magnetic nanoparticle Acoustic radiation pressure Particle trajectory Targeted drug delivery

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Author: Barnsley, LC - institutionUniversity of Oxford Oxford, MPLS, Engineering Science - - - Carugo, D - institutionUniversity of Oxfor

Source: https://ora.ox.ac.uk/objects/uuid:e4c56b38-530e-4cb4-bd20-d3a5f6a047bc



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