Expression of CDKN1C in the bone marrow of patients with myelodysplastic syndrome and secondary acute myeloid leukemia is associated with poor survival after conventional chemotherapyReport as inadecuate




Expression of CDKN1C in the bone marrow of patients with myelodysplastic syndrome and secondary acute myeloid leukemia is associated with poor survival after conventional chemotherapy - Download this document for free, or read online. Document in PDF available to download.

Reference: Radujkovic, A, Dietrich, S, Andrulis, M et al., (2016). Expression of CDKN1C in the bone marrow of patients with myelodysplastic syndrome and secondary acute myeloid leukemia is associated with poor survival after conventional chemotherapy. International Journal of Cancer, 139 (6), 1402–1413.Citable link to this page:

 

Expression of CDKN1C in the bone marrow of patients with myelodysplastic syndrome and secondary acute myeloid leukemia is associated with poor survival after conventional chemotherapy

Abstract: We tested the hypothesis, that proliferative activity of hematopoietic stem cells has impact on survival in newly diagnosed patients with myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (AML). RNA expression profiles of CD34(+) cells were analyzed in 125 MDS patients and compared to healthy controls. Prognostic impact on overall survival (OS) of mRNA proliferation signatures established for solid tumor cells was analyzed retrospectively. For validation on the protein level, immunofluorescence and immunohistochemistry analyses in bone marrow (BM) biopsies were performed, and an independent cohort of 223 MDS and secondary AML patients was investigated. Lower proliferative activity correlated with the expression of cyclin dependent kinase inhibitor 1C (CDKN1C) and with shorter OS (P



Author: Radujkovic, A - - - Dietrich, S - - - Andrulis, M - - - Benner, A - - - Longerich, T - - - Pellagatti, A - institutionUniversity

Source: https://ora.ox.ac.uk/objects/uuid:2e0edf58-fcec-4e0b-b25d-ddc6a542f9d7



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