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Reference: Oueis, E, Nardone, B, Jaspars, M et al., (2016). Synthesis of hybrid cyclopeptides through enzymatic macrocyclization. ChemistryOpen, 6 (1), 11-14.Citable link to this page:


Synthesis of hybrid cyclopeptides through enzymatic macrocyclization.

Abstract: Natural products comprise a diverse array of molecules, many of which are biologically active. Most natural products are derived from combinations of polyketides, peptides, sugars, and fatty-acid building blocks. Peptidic macrocycles have attracted attention as potential therapeutics possessing cell permeability, stability, and easy-to-control variability. Here, we show that enzymes from the patellamide biosynthetic pathway can be harnessed to make macrocycles that are hybrids of amino acids and a variety of manmade chemical building blocks, including aryl rings, polyethers, and alkyl chains. We have made macrocycles with only three amino acids, one of which can be converted to a thiazoline or a thiazole ring. We report the synthesis of 18 peptide hybrid macrocycles, nine of which have been isolated and fully characterized.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's version Funder: European Research Council   Funder: Biotechnology and Biological Sciences Research Council   Funder: Wellcome Trust   Notes:© 2016 The Authors. Published by Wiley-VCH Verlag GmbH and Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Bibliographic Details

Publisher: Wiley

Publisher Website:

Journal: ChemistryOpensee more from them

Publication Website:

Volume: 6

Issue: 1

Issue Date: 2016-12



Eissn: 2191-1363

Uuid: uuid:8f15c280-9f09-4815-8f24-3528eac5b1d9

Urn: uri:8f15c280-9f09-4815-8f24-3528eac5b1d9

Pubs-id: pubs:699005 Item Description

Type: journal-article;

Language: eng

Version: Publisher's versionKeywords: biotransformation cyanobactin hybrid macrocycles macrocyclization peptides


Author: Oueis, E - - - Nardone, B - - - Jaspars, M - - - Westwood, NJ - - - Naismith, JH - Oxford, MSD, NDM - - - - Bibliographic Details



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