A randomized trial of vitamin D supplementation on vascular function in CKDReport as inadecuate




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Reference: Kumar, V, Yadav, AK, Lal, A et al., (2017). A randomized trial of vitamin D supplementation on vascular function in CKD. Journal of the American Society of Nephrology.Citable link to this page:

 

A randomized trial of vitamin D supplementation on vascular function in CKD

Abstract: Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovascular disease risk in CKD. In this randomized, double-blind, placebo-controlled trial, we investigated the effect of cholecalciferol supplementation on vascular function in 120 patients of either sex, aged 18-70 years, with nondiabetic CKD stage 3-4 and vitamin D deficiency (serum 25-hydroxyvitamin D ≤20 ng/ml). We randomized patients using a 1:1 ratio to receive either two directly observed oral doses of cholecalciferol (300,000 IU) or matching placebo at baseline and 8 weeks. The primary outcome was change in endothelium-dependent brachial artery flow-mediated dilation at 16 weeks. Secondary outcome measures included changes in pulse wave velocity and circulating biomarkers. Cholecalciferol supplementation significantly increased endothelium-dependent brachial artery flow-mediated dilation at 16 weeks, whereas placebo did not (between-group difference in mean change: 5.49%; 95% confidence interval, 4.34% to 6.64%; P



Author: Kumar, V - - - Yadav, AK - - - Lal, A - - - Kumar, V - - - Singhal, M - - - Billot, L - - - Gupta, KL - - - Banerjee, D - - - Jha

Source: https://ora.ox.ac.uk/objects/uuid:34491a17-7637-41dd-8ced-fd04775665ac



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