Synthesis of a versatile S-3-hydroxymethylbutane-1,2,4-triol building block and its application for the stereoselective synthesis of N-homoceramidesReport as inadecuate




Synthesis of a versatile S-3-hydroxymethylbutane-1,2,4-triol building block and its application for the stereoselective synthesis of N-homoceramides - Download this document for free, or read online. Document in PDF available to download.

(2005)ORGANIC LETTERS.7(26).p.5769-5772 Mark abstract A versatile (S)-3-(hydroxymethyl)butane-1,2,4-triol building block has been synthesized starting from D-isoascorbic acid, a common food preservative. The key transformation in this approach was the introduction of branching through a high yield and fully regioselective epoxide opening. This flexible synthon has been elaborated to a new class of (dihydro-)N-homo(phyto)ceramides.

Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-325176



Author: Ulrik Hillaert and Serge Van Calenbergh

Source: https://biblio.ugent.be/publication/325176



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