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(2012)JOURNAL OF THE AMERICAN CHEMICAL SOCIETY.134(26).p.10737-10740 Mark abstract A new biocompatible strategy for photoinduced DNA interstrand cross-linking is presented. Methylene blue induced O-1(2) formation triggers furan oxidation; the resulting aldehyde then rapidly reacts with complementary A or C with formation of stable adducts. Easily accessible furan modified nucleosides, a commercially available photosensitizer, and visible light irradiation constitute the necessary tools to achieve selective duplex interstrand cross-linking

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Author: Marieke Op de Beeck and Annemieke Madder



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