Improving inhaler adherence in patients with Chronic Obstructive Pulmonary Disease : a cost-effectiveness analysisReport as inadecuate




Improving inhaler adherence in patients with Chronic Obstructive Pulmonary Disease : a cost-effectiveness analysis - Download this document for free, or read online. Document in PDF available to download.

(2014)RESPIRATORY RESEARCH.15. Mark abstract Background: The PHARMACOP-intervention significantly improved medication adherence and inhalation technique for patients with COPD compared with usual care. This study aimed to evaluate its cost-effectiveness.Methods: An economic analysis was performed from the Belgian healthcare payer’s perspective. A Markov model was constructed in which a representative group of patients with COPD (mean age of 70 years, 66% male, 43% current smokers and mean Forced Expiratory Volume in 1 second of % predicted of 50), was followed for either receiving the 3-month PHARMACOP-intervention or usual care. Three types of costs were calculated: intervention costs, medication costs and exacerbation costs. Outcome measures included the number of hospital-treated exacerbations, cost per prevented hospital-treated exacerbation and cost per Quality Adjusted Life-Year.Follow-up was 1 year in the basecase analysis. Sensitivity and scenario analyses (including long-term follow-up) were performed to assess uncertainty.Results: In the basecase analysis, the average overall costs per patient for the PHARMACOP-intervention and usual care were €2,221 and € 2,448, respectively within the 1-year time horizon. This reflects cost savings of € 227 for the PHARMACOP-intervention. The PHARMACOP-intervention resulted in the prevention of 0.07 hospital-treated exacerbations per patient (0.177 for PHARMACOP versus 0.244 for usual care). Results showed robust cost-savings in various sensitivity analyses.Conclusions: Optimization of current pharmacotherapy (e.g. close monitoring of inhalation technique and medication adherence) has been shown to be cost-saving and should be considered before adding new therapies.

Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-4427716



Author: Job FM van Boven, Eline Tommelein , Koen Boussery , Els Mehuys , Stefan Vegter, Guy Brusselle , Maureen PMH Rutten-van Mölken and

Source: https://biblio.ugent.be/publication/4427716



DOWNLOAD PDF




Related documents