The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumoursReport as inadecuate




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(2014)INTERNATIONAL JOURNAL OF ONCOLOGY.44(4).p.1015-1022 Mark abstract Primary liver tumours have a high incidence and mortality. The most important forms are hepatocellular carcinoma and intrahepatic cholangiocarcinoma, both can occur together in the mixed phenotype hepatocellular-cholangiocarcinoma. Liver progenitor cells (LPCs) are bipotential stem cells activated in case of severe liver damage and are capable of forming both cholangiocytes and hepatocytes. Possibly, alterations in Wnt, transforming growth factor-, Notch and hypoxia pathways in these LPCs can cause them to give rise to cancer stem cells, capable of driving tumourigenesis. In this review, we summarize and discuss current knowledge on the role of these pathways in LPC activation and differentiation during hepatocarcinogenesis.

Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-4403753



Author: Eliene Bogaerts , Femke Heindryckx, Yves-Paul Vandewynckel, Leo A Van Grunsven and Hans Van Vlierberghe

Source: https://biblio.ugent.be/publication/4403753



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