Marine sponge BisIndole alkaloids that displace ligand binding to α1 adrenergic receptors.Report as inadecuate


 Marine sponge BisIndole alkaloids that displace ligand binding to α1 adrenergic receptors.


Marine sponge BisIndole alkaloids that displace ligand binding to α1 adrenergic receptors. - Download this document for free, or read online. Document in PDF available to download.



Type of Resource: text

Genre: article

Issuance: single unit

Date Issued: 1996

Publisher: Elsevier B.V.

Extent: 5 p.

Physical Description: pdf

Language(s): English

Identifier: 3331919 (digitool), FADT3331919 (IID), fau:6154 (fedora)

Note(s): The α1 adrenergic receptor assay guided fractionation of an extract from the marine sponge Spongosorites sp. led to the isolation of topsentin-B2 (bromotopsentin) as the active compound. Topsentin-B2 and five related bis(indole) marine sponge metabolites were shown to displace ligand binding to α1a and α1b adrenergic receptors with Ki values for the α1b receptor ranging from 0.08 to 1.15 μM. All six compounds show selectivity for α1b relative to α1a adrenergic receptors. Marine sponge bis(indole) alkaloids such as topsentin-B2 (1) were shown to displace ligand binding to α1 adrenergic receptors. Six marine sponge derived bis(indoles) preferentially displaced ligand binding to α1b over α 1a adrenergic receptors with α1b Ki values ranging from 0.08 to 1.15 μM.This manuscript is an author version with the final publication available at http://www.sciencedirect.com/science/journal/0960894X and may be cited as: Phife, D. W., Ramos, R. A., Feng, M., King. I., Gunasekera, S. P., Wright, A., Patel, M., Pachter, J. A., & Coval, S. J. (1996). Marine sponge Bis(Indole) alkaloids that displace ligand binding to a1 adrenergic receptors. Bioorganic & Medicinal Chemistry Letters, 6(17), 2103-2106. doi:10.1016/0960-894X(96)00376-9Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1168.

Subject(s): SpongesIndole alkaloidsAdrenergic alpha blockersAlpha adrenoceptorsLigand binding (Biochemistry)

Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/3331919

Links: http://dx.doi.org/10.1016/0960-894X(96)00376-9

Restrictions on Access: ©1996 Elsevier B.V.

Owner Institution: FAU



Author: Phife, D. W., creator Ramos, R. A., creator Feng, M., creator King. I., creator Gunasekera, S. P., creator Wright, A., creator Pa

Source: http://fau.digital.flvc.org/islandora/object/fau%3A6154



DOWNLOAD PDF




Related documents