Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in FranceReport as inadecuate




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Environmental Health

, 16:77

Environmental Epidemiology

Abstract

BackgroundFew epidemiological studies have investigated the link between occupational exposure to solvents and head and neck cancer risk, and available findings are sparse and inconsistent. The objective of this study was to examine the association between occupational exposure to chlorinated solvents and head and neck cancer risk.

MethodsWe analyzed data from 4637 men 1857 cases and 2780 controls included in a population-based case-control study, ICARE France. Occupational exposure to five chlorinated solvents perchloroethylene PCE, trichloroethylene TCE, methylene chloride MC, chloroform CF, and carbon tetrachloride CT was assessed through job-exposure matrices. Odds ratios ORs and confidence intervals 95% CI were estimated by unconditional logistic regression, adjusted for age, tobacco smoking, alcohol consumption, asbestos exposure, and other potential confounders.

ResultsWe observed no association between chlorinated solvent exposure and head and neck cancer risk, despite a non-significant increase in risk among subjects who had the highest cumulative level of exposure to PCE, OR = 1.81; 95% CI = 0.68 to 4.82. In subsite analysis, the risk of laryngeal cancer increased with cumulative exposure to PCE p for trend = 0.04. The OR was 3.86 95% CI = 1.30 to 11.48 for those exposed to the highest levels of PCE. A non-significant elevated risk of hypopharyngeal cancer was also observed in subjects exposed to the highest levels of MC OR = 2.36; 95% CI = 0.98 to 5.85.

ConclusionOur findings provide evidence that high exposure to PCE increases the risk of laryngeal cancer, and suggest an association between exposure to MC and hypopharyngeal cancer. Exposure to other chlorinated solvents was not associated with the risk of head and neck cancer.

KeywordsCancer Occupation Solvents Epidemiology AbbreviationsCEICumulative exposure index

CFChloroform

CIConfidence interval

CTCarbon tetrachloride

MCMethylene chloride

OROdds-ratio

PCEPerchloroethylene

TCETrichloroethylene

Electronic supplementary materialThe online version of this article doi:10.1186-s12940-017-0286-5 contains supplementary material, which is available to authorized users.

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Author: Christine Barul - Aurore Fayossé - Matthieu Carton - Corinne Pilorget - Anne-Sophie Woronoff - Isabelle Stücker - Danièle

Source: https://link.springer.com/



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