A retrospective study of reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors and sex cord-stromal tumorsReport as inadecuate




A retrospective study of reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors and sex cord-stromal tumors - Download this document for free, or read online. Document in PDF available to download.

Journal of Ovarian Research

, 10:52

First Online: 27 July 2017Received: 07 April 2017Accepted: 19 July 2017

Abstract

BackgroundTo retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors MOGCT and sex cord-stromal tumors SCST.

MethodsData from 32 MOGCT 6 dysgerminomas, 6 yolk sac tumors, 17 immature teratomas, and 3 mixed germ cell tumors and 9 SCST 4 granulosa cell tumors and 5 sertoli-leydig cell tumors aged from 18 to 35, treated in the Obstetrics and Gynecology Hospital of Fudan University from October 2003 to October 2013 were collected and analyzed.

ResultsAverage follow up was 86.3 ± 34.4 months. Average diagnosed age was 25.3 ± 3.5 years. Average chemotherapy course was 4.4 ± 1.3 times. Patients are all living. Thirty one patients 75.6% reported normal menstrual cycles. Twelve patients 29.3% wished to conceive, 10 83.3% naturally conceived and 8 66.7% had lived birth.

ConclusionsReproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in MOGCT and SCST are favorable, meanwhile education and consultation is needed.

KeywordsMalignant germ cell tumors Malignant sex cord-stromal tumors Fertility-sparing surgery Postoperative adjuvant chemotherapy Reproductive outcomes AbbreviationsAFPα-fetoprotein

BEPBleomycin, etoposide, and cisplatin

BVPBleomycin-vincristine-platinum

FIGOInternational Federation of Gynecology and Obstetrics

GnRHaGonadotropin-releasing hormone agonists

HCGHuman choionic gonadotophin

MOGCTMalignant ovarian germ cell tumors

NCCNAmerican National Comprehensive Cancer Network

SCSTSex cord-stromal tumors

VACVincristine-actinomycin-cyclophosphamide

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Author: Ning Zhang - Ruifang Chen - Keqin Hua - Ying Zhang

Source: https://link.springer.com/







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