Effect of lysine supplementation on hypertensive men and women in selected peri-urban community in GhanaReport as inadecuate




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BMC Nutrition

, 3:67

Clinical nutrition

Abstract

BackgroundLysine is one of the essential amino acids and in cereal based diets it is known to be the most limiting and therefore determines the quality of dietary protein in such diets. This study investigated the effect of lysine supplementation on blood pressure of hypertensive adults in selected peri-urban community in Accra, Ghana.

MethodsThe study was a randomized double-blind controlled study made up of adults men and women assigned to a lysine supplemented group and a placebo-supplemented control group. The subjects aged between 18 – 45 years and totaling 180.

ResultsTotal of 50 28% of the participating were hypertensive defined as Systolic Blood Pressure SBP ≥140 mmHg. The mean SBP of lysine-supplemented group significantly dropped from 146.11 ± 11.92 to 128.95 ± 10.44 mmHg p = 0.02. That of women also dropped from 144.12 ± 10.41 to 132.28 ± 10.69 mmHg, p = 0.06 while the control group had there SBP remained fairly constant after 112 days of intervention with changes in men from 145.79 ± 12.56 to 142.79 ± 11.07 mmHg p = 0.32 and women in the control had very little drop from 145.15 ± 14.79 to 145.00 ± 17.93 mmHg p = 0.96.

ConclusionLysine supplementation resulted in normalization-reduction of blood pressure of hypertensive subjects who have suboptimal lysine intake.

KeywordsLysine Hypertension Placebo Supplementation AbbreviationsANOVAAnalysis of variance

APAnimal protein

BPBlood pressure

CPCereal protein

EAREstimated average requirements

FAOFood and agriculture organization

GABAGamma-aminobutyric acid

PDCAASProtein Digestibility Corrected Amino Acid Score

PSpulse-soy protein

RDARecommended dietary allowance

SBPSystolic blood pressure

SPSSStatistic package for social sciences

WHOWorld health organization

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Author: Frederick Vuvor - Husein Mohammed - Thomas Ndanu - Obed Harrison

Source: https://link.springer.com/







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