Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattleReport as inadecuate




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Acta Veterinaria Scandinavica

, 59:51

First Online: 27 July 2017Received: 28 April 2017Accepted: 19 July 2017

Abstract

Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia–Pacific region. Genetic variables of the major piroplasm surface protein MPSP expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.

KeywordsAnemia Major piroplasm surface protein MPSP type 1 Theileria orientalis AbbreviationsEDTAethylenediaminetetraacetic acid

Hbhemoglobin

HCThematocrit

MCHmean corpuscular hemoglobin

MCHCmean corpuscular hemoglobin concentration

MCVmean cell volume

MPSPmajor piroplasm surface protein

PCRpolymerase chain reaction

RBCred blood cell

rRNAribosomal RNA

T. orientalisTheileria orientalis

Suhee Kim and Do-Hyeon Yu contributed equally to this work

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