Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chickenReport as inadecuate




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Microbiome

, 5:91

First Online: 03 August 2017Received: 20 September 2016Accepted: 25 July 2017

Abstract

BackgroundReducing antibiotics overuse in animal agriculture is one key in combat against the spread of antibiotic resistance. Probiotics are a potential replacement of antibiotics in animal feed; however, it is not clear whether and how probiotics and antibiotics differ in impact on physiology and microbial ecology of host animals.

ResultsHost phenotype and fecal microbiota of broilers with either antibiotics or probiotics as feed additive were simultaneously sampled at four time points from birth to slaughter and then compared. Probiotic feeding resulted in a lower feed conversion ratio FCR and induced the highest level of immunity response, suggesting greater economic benefits in broiler farming. Probiotic use but not antibiotic use recapitulated the characteristics of age-dependent development of gut microbiota in the control group. The maturation of intestinal microbiota was greatly accelerated by probiotic feeding, yet significantly retarded and eventually delayed by antibiotic feeding. LP-8 stimulated the growth of many intestinal Lactobacillus spp. and led to an altered bacterial correlation network where Lactobacillus spp. are negatively correlated with 14 genera and positively linked with none, yet from the start antibiotic feeding featured a less-organized network where such inter-genera interactions were fewer and weaker. Consistently, microbiota-encoded functions as revealed by metagenome sequencing were highly distinct between the two groups. Thus -intestinal microbiota maturation index- was proposed to quantitatively compare impact of feed additives on animal microecology.

ConclusionsOur results reveal a tremendous potential of probiotics as antibiotics’ substitute in poultry farming.

KeywordsProbiotics Intestinal microbiota Broiler Antibiotic overuse Antibiotic resistance AbbreviationsADFIAverage daily feed intake

ADGAverage daily gain

FCRFeed conversion ratio

IgAImmune globulin A

IgGImmune globulin G

IMMIIntestinal microbiota maturation index

PCAPrinciple component analysis

SIgASecretory immune globulin A

Electronic supplementary materialThe online version of this article doi:10.1186-s40168-017-0315-1 contains supplementary material, which is available to authorized users.

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Author: Pengfei Gao - Chen Ma - Zheng Sun - Lifeng Wang - Shi Huang - Xiaoquan Su - Jian Xu - Heping Zhang

Source: https://link.springer.com/







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