Fixation of split-thickness skin graft using fast-clotting fibrin glue containing undiluted high-concentration thrombin or sutures: a comparison studyReport as inadecuate




Fixation of split-thickness skin graft using fast-clotting fibrin glue containing undiluted high-concentration thrombin or sutures: a comparison study - Download this document for free, or read online. Document in PDF available to download.

SpringerPlus

, 5:1902

Medicine

Abstract

ObjectiveFor skin defects caused by full-thickness burns, trauma, or tumor tissue excision, skin grafting is one of the most convenient and useful treatment methods. In this situation, graft fixation is important in skin grafting. This study was performed to compare the effectiveness of skin graft fixation between high-concentration fibrin sealant and sutures. There have been numerous studies using fibrin sealant for graft fixation, but they utilized slow-clotting fibrin sealant containing less than 10 IU-mL thrombin.

MethodTwenty-five patients underwent split-thickness skin grafting using fast-clotting fibrin sealant containing 400 IU-mL thrombin, while 30 patients underwent grafting using sutures. Rates of hematoma-seroma formation, graft dislocation, graft necrosis, and graft take were investigated postoperatively. The graft surface area was calculated using Image J software National Institutes of Health, Bethesda, MD, USA.

ResultAfter 5 days, rates of hematoma-seroma formation and graft dislocation were 7.84 and 1.29% in group I, and 9.55 and 1.45% in group II, respectively. After 30 days, rates of graft necrosis and graft take were 1.86 and 98.14% in group I, and 4.65 and 95.35% in group II. Undiluted fibrin sealant showed significantly superior results for all rates p < 0.05 except graft dislocation.

ConclusionWhen high-concentration fast-clotting fibrin sealant was applied to skin grafts without dilution, no difficulty was experienced during surgery. Sealant showed superior results compared with sutures and had an excellent graft take rate.

Level of evidenceII.

KeywordsFibrin sealant Suture Thrombin Fast clotting Split-thickness skin graft  Download fulltext PDF



Author: Hyun Ho Han - Daiwon Jun - Suk-Ho Moon - In Sook Kang - Min Cheol Kim

Source: https://link.springer.com/







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