Triglyceride to high-density lipoprotein cholesterol ratio predicts cardiovascular events in maintenance hemodialysis patientsReport as inadecuate




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Renal Replacement Therapy

, 2:60

First Online: 10 November 2016Received: 16 April 2016Accepted: 18 October 2016

Abstract

BackgroundThe triglyceride to high-density lipoprotein cholesterol TG-HDL-C ratio has been shown to be a predictor of cardiovascular CV outcomes in the general population. The aim of this study was to determine whether the TG-HDL-C ratio is a predictor of CV events and all-cause mortality in maintenance hemodialysis MHD patients.

MethodsWe performed a retrospective, observational cohort study in which we enrolled 193 MHD patients from a single center in Japan who had been followed up for a median of 3.9 years. The outcomes were the occurrence of a CV event and all-cause mortality during the follow-up period. Baseline TG-HDL-C ratios were investigated for associations with outcomes by using Cox regression models adjusted for demographic parameters.

ResultsOverall, 88 of the subjects experienced a CV event, and 32 patients had died, of whom 4 died due to CV events. Patients with higher TG-HDL-C levels tertile 3 had a higher incidence of CV events adjusted hazard ratio HR 1.82, 95 % confidence interval CI 1.01–3.35 and higher all-cause mortality adjusted HR 6.13, 95 % CI 2.13–20.22 than the patients in tertile 1. Kaplan–Meier analyses by the log-rank test showed that the TG-HDL-C ratio had significant predictive power for detecting a CV event.

ConclusionsThe TG-HDL-C ratio is a reliable and easily accessible marker for predicting CV events and mortality in MHD patients.

KeywordsTriglyceride to HDL cholesterol ratio Cardiovascular events Hemodialysis Survival AbbreviationsBPBlood pressure

CKDChronic kidney disease

DMDiabetes mellitus

HDL-CHigh-density lipoprotein cholesterol

MHDMaintenance hemodialysis

TGTriglyceride

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Author: Ayako Hasegawa - Fumiko Kojima - Mio Ueda - Yoshiko Tanaka - Kosaku Nitta

Source: https://link.springer.com/



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