IL28B genotype is associated with cirrhosis or transition to cirrhosis in treatment-naive patients with chronic HCV genotype 1 infection: the international observational Gen-C studyReport as inadecuate




IL28B genotype is associated with cirrhosis or transition to cirrhosis in treatment-naive patients with chronic HCV genotype 1 infection: the international observational Gen-C study - Download this document for free, or read online. Document in PDF available to download.

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, 5:1990

Medicine

Abstract

Background and purposeContradictory data exist on the association between host interleukin-28B IL28B rs12979860 genotype and liver fibrosis in patients with chronic hepatitis C CHC. This large, international, observational study NCT01675427-MV25600 investigated relationships between IL28B rs12979860 genotype and liver fibrosis stage in CHC patients.

MethodsA total of 3003 adult, treatment-naive CHC patients were enrolled into the study. Patients made one study visit to provide a blood sample for genotyping; other data were obtained from medical records.

Results2916 patients comprised the analysis population; the majority were enrolled in Europe n = 2119, were Caucasian n = 2582 and had hepatitis C virus HCV genotype G1 infection n = 1702 G2 = 323, G3 = 574, G4 = 260. Distribution of IL28B genotypes varied according to region of enrolment, patient ethnicity and HCV genotype. A significant association was observed between increasing number of IL28B T alleles and the prevalence of cirrhosis-transition to cirrhosis based on biopsy or non-invasive assessments in G1-infected patients CC = 22.2% 111-499, CT = 27.5% 255-928, TT = 32.3% 87-269; p = 0.0018. The association was significant in the large subgroup of European Caucasian G1 patients n = 1245 but not in the smaller Asian n = 25, Latin American n = 137 or Middle Eastern n = 289 G1 subgroups. IL28B genotype was not associated with liver fibrosis stage in patients with HCV G2, G3 or G4 infection.

ConclusionThis large, international study found that IL28B rs12979860 genotype is significantly associated with liver fibrosis stage in CHC patients with HCV G1 infection. This association was evident in European Caucasians but not in G1-infected patients from Asia, Latin America or the Middle East.

KeywordsHepatitis C Gen-C study IL28B Advanced fibrosis Chronic hepatitis C AbbreviationsALTalanine transaminase

ASTaspartate transaminase

APRIAST to platelet ratio

CHCchronic hepatitis C

HCVhepatitis C virus

Ggenotype

IFNinterferon

IL28Binterleukin 28B

MLRmultiple logistic regression

SNPsingle nucleotide polymorphism

SVRsustained virological response

TLRtoll-like receptor

Electronic supplementary materialThe online version of this article doi:10.1186-s40064-016-3663-6 contains supplementary material, which is available to authorized users.

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Author: Alessandra Mangia - Victor De Ledinghen - François Bailly - Javier Brahm - Jazeps Keiss - Jonas Valantinas - Nele Rasmann

Source: https://link.springer.com/



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