Curcumin and tumor immune-editing: resurrecting the immune systemReport as inadecuate




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Cell Division

, 10:6

First Online: 12 October 2015Received: 01 July 2015Accepted: 21 September 2015

Abstract

Curcumin has long been known to posses medicinal properties and recent scientific studies have shown its efficacy in treating cancer. Curcumin is now considered to be a promising anti-cancer agent and studies continue on its molecular mechanism of action. Curcumin has been shown to act in a multi-faceted manner by targeting the classical hallmarks of cancer like sustained proliferation, evasion of apoptosis, sustained angiogenesis, insensitivity to growth inhibitors, tissue invasion and metastasis etc. However, one of the emerging hallmarks of cancer is the avoidance of immune system by tumors. Growing tumors adopt several strategies to escape immune surveillance and successfully develop in the body. In this review we highlight the recent studies that show that curcumin also targets this process and helps restore the immune activity against cancer. Curcumin mediates several processes like restoration of CD4-CD8 T cell populations, reversal of type-2 cytokine bias, reduction of Treg cell population and suppression of T cell apoptosis; all these help to resurrect tumor immune surveillance that leads to tumor regression. Thus interaction of curcumin with the immune system is also an important feature of its multi-faceted modes of action against cancer. Finally, we also point out the drawbacks of and difficulties in curcumin administration and indicate the use of nano-formulations of curcumin for better therapeutic efficacy.

Keywords3-Es Curcumin Hallmarks of cancer Nanocurcumin Tumor immune-editing Tumor immunesurveillance AbbreviationsBCL2B-cell lymphoma 2

CDKcyclin dependent kinase

DMSOdimethyl sulfoxide

EGFRepidermal growth factor receptor

FLIPFLICE inhibitory protein

FOXP3Forkhead Box P3

IκBinhibitor of κB

IKKinhibitor of κB kinase

iNOSinducible nitric oxide synthase

JAKJanus kinase

JNKcJUN N-terminal kinase

MAPKmitogen-activated protein kinase

mTORmammalian target of rapamycin

NF-κBnuclear factor κB

PI3Kphosphatidylinositol-3-kinase

PKCprotein kinase C

PRBretinoblastoma protein

PUMAP53 upregulated modulator of apoptosis

STATsignal transducer and activator of transcription

Th1T-helper1

Th2T-helper 2

TregT regulatory cells

VEGFvascular endothelial growth factor

XIAPX-linked inhibitor of apoptosis

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Author: Sayantan Bose - Abir Kumar Panda - Shravanti Mukherjee - Gaurisankar Sa

Source: https://link.springer.com/



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