The nutritional composition and anti-obesity effects of an herbal mixed extract containing Allium fistulosum and Viola mandshurica in high-fat-diet-induced obese miceReport as inadecuate




The nutritional composition and anti-obesity effects of an herbal mixed extract containing Allium fistulosum and Viola mandshurica in high-fat-diet-induced obese mice - Download this document for free, or read online. Document in PDF available to download.

BMC Complementary and Alternative Medicine

, 15:370

First Online: 16 October 2015Received: 05 July 2015Accepted: 23 September 2015

Abstract

BackgroundIn traditional oriental medicine, A. fistulosum and V. mandshurica are considered to be effective in promoting blood circulation. Therefore, in this study, we investigated whether a solution containing both A. fistulosum and V. mandshurica AFE + VME extracts has synergistic effects on the treatment of hyperlipidemia and obesity.

MethodsAnti-obesity effects of an herbal extract containing Allium fistulosum and Viola mandshurica AFE + VME were investigated in high-fat diet HFD-induced obese mice. AFE + VME was orally administrated to mice with the HFD at a dose of 200 mg-kg-day for 8 weeks. We observed the effects of mixed extract on body weight, fat mass, serum lipid levels, and mRNA expression levels of lipid metabolism-related genes in the adipose tissue of mice.

ResultsThe nutritional analysis revealed that this mixed extract is high in carbohydrate 72.2 g-100 g and protein 11.5 g-100 g; low in fat 1.7 g-100 g; rich in vitamins E 4.8 mg-100 g, B1 14.8 mg-100 g, B2 1.0 mg-100 g, niacin 7.9 mg-100 g, and folic acid 1.57 mg-100 g; and rich in minerals such as calcium 600 mg-100 g, iron 106.1 mg-100 g, and zinc 5.8 mg-100 g. The oral administration of AFE + VME in obese mice reduced body weight, tissue weight, adipocyte size, and lipid accumulation in the liver compared with HFD control mice. AFE + VME also decreased serum triglyceride, total cholesterol, and leptin concentrations. Furthermore, AFE + VME markedly increased the mRNA expression of peroxisome proliferator-activated receptor-γ PPAR-γ, uncoupling protein-2 UCP-2, and adiponectin and decreased leptin expression in the epididymal white adipose tissue. Our results suggest that the extract containing A. fistulosum and V. mandshurica improved lipid metabolism via the up-regulation of PPAR-γ, UCP-2, and adiponectin expression and the down-regulation of leptin in HFD-induced obese mice.

ConclusionsTherefore, the extract containing Allium fistulosum and Viola mandshurica may be a potentially effective therapy for obesity and its related metabolic disorders such as hyperlipidemia and insulin resistance.

KeywordsAllium fistulosum Hyperlipidemia Mixture Nutritional Viola mandshurica Vitamin AbbreviationsAFEAllium fistulosum extract

ALTAlanine aminotransferase

ASTAspartate aminotransferase

FERFood efficiency ratio

HDLHigh-density lipoprotein

HFDHigh fat diet

LDLLow-density lipoprotein

NDNormal diet

PPAR-γPeroxisome proliferator-activated receptor-γ

RDARecommended daily allowance

UCP-2Uncoupling protein-2

VMEViola mandshurica extract

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Author: Yoon-Young Sung - Seung-Hyung Kim - Byoung Wan Yoo - Ho Kyoung Kim

Source: https://link.springer.com/



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