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BMC Complementary and Alternative Medicine

, 15:372

First Online: 16 October 2015Received: 29 March 2015Accepted: 07 October 2015

Abstract

BackgroundThe relation between tongue color and gastroesophageal disease is unclear. This study was done to investigate the associations between tongue color TC, endoscopic findings, Helicobacter.pylori infection status, and serological atrophic gastritis SAG.

MethodsThe participants were 896 residents of Ishigaki Island, Okinawa, aged 28–86 years. The tongue was photographed, esophagogastroduodenoscopy was done, and serum antibody to H.pylori was measured. SAG was defined as a serum Pepsinogen PGIlevel ≤70 ng-ml and a PGI-IIratio ≤3.0. TC was measured by the device-independent international commission on Illumination 1976 L*a*b* color space standards at four points: 1 edge, 2 posterior, 3 middle, and 4 apex. We also calculated the ratio of the tongue edge to the three other measured points to examine the association between the coating of the tongue and the endoscopic and laboratory findings.

ResultsParticipants were excluded who had two or more endoscopic findings n = 315 or who had SAG without seropositivity to H.pylori n = 33. The remaining 548 participants were divided into three groups: SAG and seropositive to H.pylori n = 67, seropositive to H.pylori alone n = 56, and without SAG and seronegative for H.pylori n = 425. We divided 425 residents into a single endoscopic finding positive group n = 207 and a negative group, which served as a control n = 218. The most frequent single endoscopic finding was esophageal hernia n = 110, followed by erosive esophagitis n = 35 and erosive gastritis EG n = 45. EH was significantly associated with TC 2b*-1b* P < 0.05. EG was significantly associated with TC 3a*, 3b* P < 0.05. Seropositivity to H.pylori was significantly associated with TC 3 L*, 3 L*-1 L* P < 0.05, <0.01, and seropositivity to both H.pylori and SAG was significantly associated with TC 3 L*-1 L* P < 0.05. Multivariate analysis extracted TC 3a*, 3b* as an independent factor associated with a differential diagnosis of EG Odds ratio OR 2.66 P = 0.008, OR 2.17 P = 0.045.

ConclusionsThe tongue body color of the middle area reflects acute change of gastric mucosa, such as erosive gastritis. Tongue diagnosis would be a useful, non-invasive screening tool for EG.

KeywordsTongue color Endoscopic finding Helicobacter pylori Evidenced Based Medicine AbbreviationsCIEcommission on Illumination

DCDuodenal cancer

DUDuodenal ulcer

GCGastric cancer

GUGastric ulcer

EDErosive duodenitis

EEErosive esophagitis

EGErosive gastiritis

EHEsophageal hernia

H.pylori +ant-H.pylori antibody positive

PGPepsinogen

SAGserological atrophic gastritis

SGSuperficial gastritis

TCtongue color

TIAStongue imaging analysis system

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Author: Mosaburo Kainuma - Norihiro Furusyo - Yoshihisa Urita - Masaharu Nagata - Takeshi Ihara - Takeshi Oji - Toshiya Nakaguchi -

Source: https://link.springer.com/







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