Non-coding yet non-trivial: a review on the computational genomics of lincRNAsReport as inadecuate




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BioData Mining

, 8:44

First Online: 22 December 2015Received: 27 June 2015Accepted: 04 December 2015

Abstract

Long intergenic non-coding RNAs lincRNAs represent one of the most mysterious RNA species encoded by the human genome. Thanks to next generation sequencing NGS technology and its applications, we have recently witnessed a surge in non-coding RNA research, including lincRNA research. Here, we summarize the recent advancement in genomics studies of lincRNAs. We review the emerging characteristics of lincRNAs, the experimental and computational approaches to identify lincRNAs, their known mechanisms of regulation, the computational methods and resources for lincRNA functional predictions, and discuss the challenges to understanding lincRNA comprehensively.

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Author: Travers Ching - Jayson Masaki - Jason Weirather - Lana X. Garmire

Source: https://link.springer.com/







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