Effects of exercise training on pulmonary vessel muscularization and right ventricular function in an animal model of COPDReport as inadecuate

Effects of exercise training on pulmonary vessel muscularization and right ventricular function in an animal model of COPD - Download this document for free, or read online. Document in PDF available to download.

Respiratory Research

, 15:117

First Online: 28 September 2014Received: 04 June 2014Accepted: 17 September 2014


BackgroundRight ventricular dysfunction in COPD is common, even in the absence of pulmonary hypertension. The aim of the present study was to examine the effects of high intensity interval training HIIT on right ventricular RV function, as well as pulmonary blood vessel remodeling in a mouse model of COPD.

Methods42 female A-JOlaHsd mice were randomized to exposure to either cigarette smoke or air for 6 hours-day, 5 days-week for 14 weeks. Mice from both groups were further randomized to sedentariness or HIIT for 4 weeks. Cardiac function was evaluated by echocardiography and muscularization of pulmonary vessel walls by immunohistochemistry.

ResultsSmoke exposure induced RV systolic dysfunction demonstrated by reduced tricuspid annular plane systolic excursion. HIIT in smoke-exposed mice reversed RV dysfunction. There were no significant effects on the left ventricle of neither smoke exposure nor HIIT. Muscularization of the pulmonary vessels was reduced after exercise intervention, but no significant effects on muscularization were observed from smoke exposure.

ConclusionsRV function was reduced in mice exposed to cigarette smoke. No Increase in pulmonary vessel muscularization was observed in these mice, implying that other mechanisms caused the RV dysfunction. HIIT attenuated the RV dysfunction in the smoke exposed mice. Reduced muscularization of the pulmonary vessels due to HIIT suggests that exercise training not only affects the heart muscle, but also has important effects on the pulmonary vasculature.

KeywordsCOPD Exercise Animal model Cardiac function Right ventricle Pulmonary vessel remodeling Electronic supplementary materialThe online version of this article doi:10.1186-s12931-014-0117-y contains supplementary material, which is available to authorized users.

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Author: Erlend Hassel - Anne Marie Berre - Anne Jarstein Skjulsvik - Sigurd Steinshamn

Source: https://link.springer.com/

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