New approach for the treatment of osteoradionecrosis with pentoxifylline and tocopherolReport as inadecuate




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Biomaterials Research

, 18:13

First Online: 29 September 2014Received: 13 August 2014Accepted: 12 September 2014

Abstract

Osteoradionecrosis ORN of the jaw is a significant complication of radiotherapy for oral cavity cancer. In addition to antibiotic medication, treatment options such as hyperbaric oxygen therapy, surgical approaches, and combined therapy with pentoxifylline and tocopherol have been recently introduced.

In this review article, we will discuss the definition and classifications of osteoradionecrosis, its etiology and pathophysiology, previous treatment options, oral and maxillofacial complications of radiotherapy, basic information on pentoxifylline and tocopherol, recent reports of pentoxifylline and tocopherol combined therapy, and, finally, ORN-induced animal models and future approaches.

KeywordsOsteoradionecrosis ORN Pentoxifylline Tocopherol Radiotherapy Electronic supplementary materialThe online version of this article doi:10.1186-2055-7124-18-13 contains supplementary material, which is available to authorized users.

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Author: Huan Fan - Soung Min Kim - Yun Ju Cho - Mi Young Eo - Suk Keun Lee - Kyung Mi Woo

Source: https://link.springer.com/







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