The effects of treatment on lipoprotein subfractions evaluated by polyacrylamide gel electrophoresis in patients with autoimmune hypothyroidism and hyperthyroidismReport as inadecuate




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Lipids in Health and Disease

, 13:158

First Online: 10 October 2014Received: 30 July 2014Accepted: 01 October 2014

Abstract

BackgroundAtherogenic dyslipoproteinemia is one of the most important risk factor for atherosclerotic changes development. Hypothyroidism is one of the most common causes of secondary dyslipidemias which results from reduced LDL clearance and therefore raised levels of LDL and apoB. Association between small dense LDL sdLDL presentation and thyroid status has been examinated using polyacrylamide gel electrophoresis for lipoprotein subfractions evaluation.

Methods40 patients with diagnosed autoimmune hypothyroidism and 30 patients with autoimmune hyperthyroidism were treated with thyroxine replacement or thyreo-suppressive treatment. In both groups lipid profiles, LDL subractions, apolipoproteins apoA1, apoB, apoA1-apoB ratio and atherogenic index of plazma AIP were examined before treatment and in state of euthyreosis.

ResultsThyroxine replacement therapy significantly reduced levels of total cholesterol TC, LDL, triglycerides TG and also decreased levels of sdLDL 8,55±11,671 vs 0,83±1,693mg-dl; p<0,001, apoB and AIP. For estimation of atherogenic lipoprotein profile existence an AIP evaluation seems to be better than apoB measurement because of the more evident relationship with sdLDL r=0,538; p<0,01. Thyreo-suppressive therapy significantly increased levels of TC, LDL, TG and apoB. The sdLDL was not found in hyperthyroid patients.

ConclusionsAtherogenic lipoprotein profile was present in 52.5% of hypothyroid subjects, which is higher prevalence than in normal, age-related population. Substitution treatment leads to an improvement of the lipid levels, TG, apoB, AIP and LDL subclasses. It significantly changed the presentation of sdLDL – we noticed shift to large, less atherogenic LDL particles. Significantly positive correlation between sdLDL and TAG; sdLDL and VLDL alerts to hypertriglyceridemia as a major cardiovascular risk factor.

KeywordsAtherogenic dyslipidemia Hypothyroidism Small dense LDL apoB Atherogenic index of plasma Electronic supplementary materialThe online version of this article doi:10.1186-1476-511X-13-158 contains supplementary material, which is available to authorized users.

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Author: Zuzana Minarikova - Ludovit Gaspar - Peter Kruzliak - Zuzana Celecová - Stanislav Oravec

Source: https://link.springer.com/







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