Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compoundsReport as inadecuate




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Nutrition Journal

, 13:101

First Online: 18 October 2014Received: 10 June 2014Accepted: 07 October 2014

Abstract

BackgroundConsumption of a cholesterol lowering dietary portfolio including plant sterols PS, viscous fibre, soy proteins and nuts for 6 months improves blood lipid profile. Plant sterols reduce blood cholesterol by inhibiting intestinal cholesterol absorption and concerns have been raised whether PS consumption reduces fat soluble vitamin absorption.

ObjectiveThe objective was to determine effects of consumption of a cholesterol lowering dietary portfolio on circulating concentrations of PS and fat soluble vitamins.

MethodsUsing a parallel design study, 351 hyperlipidemic participants from 4 centres across Canada were randomized to 1 of 3 groups. Participants followed dietary advice with control or portfolio diet. Participants on routine and intensive portfolio involved 2 and 7 clinic visits, respectively, over 6 months.

ResultsNo changes in plasma concentrations of α and γ tocopherol, lutein, lycopene and retinol, but decreased β-carotene concentrations were observed with intensive week 12:p = 0.045; week 24:p = 0.039 and routine week 12:p = 0.031; week 24:p = 0.078 portfolio groups compared to control. However, cholesterol adjusted β-carotene and fat soluble compound concentrations were not different compared to control. Plasma PS concentrations were increased with intensive campesterol:p = 0.012; β-sitosterol:p = 0.035 and routine campesterol: p = 0.034; β-sitosterol: p = 0.080 portfolio groups compared to control. Plasma cholesterol-adjusted campesterol and β-sitosterol concentrations were negatively correlated p < 0.001 with total and LDL-C levels.

ConclusionResults demonstrate that consuming a portfolio diet reduces serum total and LDL-C levels while increasing PS values, without altering fat soluble compounds concentrations. The extent of increments of PS with the current study are not deleterious and also maintaining optimum levels of fat soluble vitamins are of paramount necessity to maintain overall metabolism and health. Results indicate portfolio diet as one of the best options for CVD risk reduction.

Trial registrationclinicaltrials.gov Identifier: NCT00438425

KeywordsPlant sterols Fat soluble vitamins Portfolio diet AbbreviationsCVDCardiovascular disease

HDL-CHigh density lipoprotein cholesterol

LDL-CLow density lipoprotein cholesterol

PSPlant sterols.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2891-13-101 contains supplementary material, which is available to authorized users.

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