Chemoselective Access to π-Conjugated Heterocycles by Stille and Sonogashira Reactions on 2-Substituted 4H-pyridoe1,3oxazin-4-onesReport as inadecuate




Chemoselective Access to π-Conjugated Heterocycles by Stille and Sonogashira Reactions on 2-Substituted 4H-pyridoe1,3oxazin-4-ones - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 IPCM - Institut Parisien de Chimie Moléculaire

Abstract : Site-selective PdII catalyzed cross-coupling reactions have been developed on 2-substituted-4H-pyridoe1,3oxazin-4-ones. C 4-and C 5-alkynylated pyridooxazinones have been thus obtained via Sonogashira reaction while the efficient incorporation at C 5 position of heteroaryl, ethenyl substituents have been achieved via Stille reaction. Finally one example of a one pot sequential multiple Sonogashira reaction with different alkynes has been realized. The strategy developed herein provides a rapid access to polyfunctionnalized precursors with extended π-conjugation for further application as fluorescent material.





Author: Laetitia Le Falher - Amara Mumtaz - Anthony Nina Diogo - Candice Botuha - Serge Thorimbert -

Source: https://hal.archives-ouvertes.fr/



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