Regional and global antimicrobial susceptibility among isolates of Streptococcus pneumoniae and Haemophilus influenzae collected as part of the Tigecycline Evaluation and Surveillance Trial T.E.S.T. from 2009 to 2012 and comparisoReport as inadecuate




Regional and global antimicrobial susceptibility among isolates of Streptococcus pneumoniae and Haemophilus influenzae collected as part of the Tigecycline Evaluation and Surveillance Trial T.E.S.T. from 2009 to 2012 and compariso - Download this document for free, or read online. Document in PDF available to download.

Annals of Clinical Microbiology and Antimicrobials

, 13:52

First Online: 07 November 2014Received: 25 July 2014Accepted: 24 October 2014

Abstract

BackgroundWe report here on 14438 Streptococcus pneumoniae and 14770 Haemophilus influenzae isolates collected from 560 centres globally between 2004 and 2012 as a part of the Tigecycline Evaluation and Surveillance Trial T.E.S.T



MethodsMIC testing was performed using broth microdilution methods as described by the Clinical and Laboratory Standards Institute CLSI using CLSI-approved breakpoints; US Food and Drug Administration breakpoints were used for tigecycline as CLSI breakpoints are not available.

ResultsAt least 99% of S. pneumoniae isolates globally were susceptible to levofloxacin, linezolid, tigecycline or vancomycin. Penicillin resistance was observed among 14.8% of S. pneumoniae and was highest in Asia-Pacific Rim 30.1% and Africa 27.6%; 23.4% of S. pneumoniae isolates were penicillin-intermediate, which were most common in Africa 37.6%. Minocycline susceptibility among S. pneumoniae decreased by 20% between 2004-2008 and 2009-2012. High >98.5% susceptibility was reported among H. influenzae to all antimicrobial agents on the T.E.S.T. panel excluding ampicillin, to which only 78.3% were susceptible. β-lactamase production was observed among 20.2% of H. influenzae isolates; 1.5% of isolates were β-lactamase negative, ampicillin-resistant.

ConclusionsS. pneumoniae remained highly susceptible to levofloxacin, linezolid, tigecycline and vancomycin while H. influenzae was susceptible to most antimicrobial agents in the testing panel excluding ampicillin.

KeywordsAntimicrobial susceptibility Streptococcus pneumoniae Haemophilus influenzae Tigecycline Electronic supplementary materialThe online version of this article doi:10.1186-s12941-014-0052-2 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Viktorija Tomic - Michael J Dowzicky

Source: https://link.springer.com/







Related documents