Efficient access to 2,6,8-trisubstituted 4-aminoquinazolines via microwave-assisted one-pot chemoselective tri-Suzuki-Miyaura or SNAr-bis-Suzuki-Miyaura reactions in waterReport as inadecuate




Efficient access to 2,6,8-trisubstituted 4-aminoquinazolines via microwave-assisted one-pot chemoselective tri-Suzuki-Miyaura or SNAr-bis-Suzuki-Miyaura reactions in water - Download this document for free, or read online. Document in PDF available to download.

1 ICR - Institut de Chimie Radicalaire

Abstract : An efficient sequential one-pot strategy for synthesizing polyfunctionalized quinazoline derivatives is presented. After selective amination of 4 at C-4 position, 2,6,8-trisubstituted 4-aminoquinazoline derivatives are prepared through one-pot chemoselective sequential tri-Suzuki-Miyaura or SNAr-bis-Suzuki-Miyaura reactions under microwave irradiation in an aqueous medium. This approach used with a variety of boronic acids affords the polysubstituted quinazoline derivatives in good to excellent yields in only a few steps and in environmentally benign solvent water.





Author: Youssef Kabri - Maxime Crozet - Thierry Terme - Patrice Vanelle -

Source: https://hal.archives-ouvertes.fr/



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