A high-protein diet for reducing body fat: mechanisms and possible caveatsReport as inadecuate




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Nutrition and Metabolism

, 11:53

First Online: 19 November 2014Received: 06 August 2014Accepted: 10 November 2014

Abstract

High protein diets are increasingly popularized in lay media as a promising strategy for weight loss by providing the twin benefits of improving satiety and decreasing fat mass. Some of the potential mechanisms that account for weight loss associated with high-protein diets involve increased secretion of satiety hormones GIP, GLP-1, reduced orexigenic hormone secretion ghrelin, the increased thermic effect of food and protein-induced alterations in gluconeogenesis to improve glucose homeostasis. There are, however, also possible caveats that have to be considered when choosing to consume a high-protein diet. A high intake of branched-chain amino acids in combination with a western diet might exacerbate the development of metabolic disease. A diet high in protein can also pose a significant acid load to the kidneys. Finally, when energy demand is low, excess protein can be converted to glucose via gluconeogenesis or ketone bodies and contribute to a positive energy balance, which is undesirable if weight loss is the goal. In this review, we will therefore explore the mechanisms whereby a high-protein diet may exert beneficial effects on whole body metabolism while we also want to present possible caveats associated with the consumption of a high-protein diet.

KeywordsHigh-protein diet Weight loss Satiety Energy expenditure Thermic effect of food  Download fulltext PDF



Author: Dominik H Pesta - Varman T Samuel

Source: https://link.springer.com/







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