Tumor necrosis factor-alpha gene −308G > A polymorphism alters the risk of hepatocellular carcinoma in a Han Chinese populationReport as inadecuate




Tumor necrosis factor-alpha gene −308G > A polymorphism alters the risk of hepatocellular carcinoma in a Han Chinese population - Download this document for free, or read online. Document in PDF available to download.

Diagnostic Pathology

, 9:199

First Online: 25 November 2014Received: 04 September 2014Accepted: 08 October 2014

Abstract

BackgroundThe aim of the present study was to evaluate the influence of tumor necrosis factor-alpha TNF-α −308 G > A polymorphism on hepatocellular carcinoma HCC risk.

MethodsThe present case–control study was conducted in a Han Chinese population consisting of 753 HCC patients and 760 controls from May 2010 to March 2013. The −308 TNF-a promoter polymorphisms were detected. Conditional logistic regression was performed to analyze the association between TNF-α −308 G > A polymorphism and the risk of HCC, which were estimated by odds ratios ORs and their 95% confidence intervals 95% CIs.

ResultsThe genotypic frequencies in the cases were not similar to that of the controls, differences being statistically significant P = 0.002. Using the GG genotype as the reference genotype, AA was significantly associated with increased risk of HCC adjusted OR = 5.12, 95% CI = 2.31–7.82. Similarly, AG + AA genotype showed 5.59-fold increased HCC risk in a dominant model. Furthermore, we found A allele was significantly associated with increased risk of HCC, compared with G allele OR = 4.18, 95% CI = 1.76–6.97.

ConclusionThe present study showed that TNF-α −308 G > A polymorphism was associated with increased HCC risk in a Han Chinese population. Further prospective studies on large and different ethnic populations will be necessary to confirm our findings and elucidate the underlying molecular mechanism for the development of HCC.

Virtual SlidesThe virtual slides for this article can be found here: http:-www.diagnosticpathology.diagnomx.eu-vs-13000 2014 199

KeywordsHepatocellular carcinoma TNF-α Genetic variant Susceptibility Risk  Download fulltext PDF



Author: Hua Feng - Jing-hua Kuai - Ming-yan Zhang - Guang-chuan Wang - Yong-jun Shi - Jun-yong Zhang

Source: https://link.springer.com/







Related documents