Use of Propranolol Blockade to Explore the Pharmacology of GSK961081, a Bi-Functional Bronchodilator, in Healthy Volunteers: Results from Two Randomized TrialsReport as inadecuate




Use of Propranolol Blockade to Explore the Pharmacology of GSK961081, a Bi-Functional Bronchodilator, in Healthy Volunteers: Results from Two Randomized Trials - Download this document for free, or read online. Document in PDF available to download.

Drugs in RandD

, Volume 14, Issue 4, pp 241–251

First Online: 30 September 2014

Abstract

PurposeThe objective of this study was to explore the pharmacology of GSK961081, a bi-functional bronchodilator, in healthy volunteers.

MethodsTwo randomized, double-blind, placebo-controlled studies were conducted. Following optimization of the propranolol dosing regimen study 1, we conducted a five-period crossover study study 2 in which subjects received the following treatments: dry powder inhaler DPI GSK961081 400 µg + oral placebo, DPI GSK961081 1,200 µg + oral placebo, DPI GSK961081 400 µg + oral propranolol 80 mg, DPI GSK961081 1,200 µg + oral propranolol 80 mg and DPI and oral placebo. GSK961081 or inhaled placebo was dosed at 0 h. Propranolol or oral placebo was dosed at −8, −2, 4, 10, and 16 h. The primary endpoint for both studies was bronchodilation, measured by specific airway conductance sGaw, which was assessed at 0, 1, 4, 7, 12, 22, and 24 h in study 2. Tolerability and pharmacokinetics were secondary endpoints.

ResultsStudies 1 and 2 enrolled 18 and 23 subjects, respectively. In study 2, bronchodilation was seen for 24 h following GSK961081 400 and 1,200 μg. In the presence of β2 blockade, GSK961081 1,200 μg demonstrated bronchodilation in the first 4 h after dosing treatment difference from placebo at 1 h: 1.206; 90 % confidence interval CI 1.126–1.292; and at 4 h: 1.124; 90 % CI 1.078–1.173 but not at 7 h onwards. In the presence of β2 blockade, GSK961081 400 μg demonstrated bronchodilation in the first 1 h after dosing treatment difference from placebo: 1.193; 90 % CI 1.117–1.274, but not at 4 h onwards. Adverse events were reported for 21 study 1 and 15 subjects study 2; none were serious, and there were no deaths.

ConclusionThe duration of bronchodilation as a result of receiving the muscarinic antagonist component alone was shorter than that from the muscarinic antagonist β2 agonist combination. Removing the β2 agonist component may underestimate the contribution of the muscarinic antagonist component to the bronchodilation of the combination.

Download fulltext PDF



Author: Virginia Norris - Claire Ambery

Source: https://link.springer.com/



DOWNLOAD PDF




Related documents