Vitamin E attenuates neurotoxicity induced by deltamethrin in ratsReport as inadecuate




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BMC Complementary and Alternative Medicine

, 14:458

Basic research

Abstract

BackgroundThe safety of Deltamethrin DM has been raised as a point of concern. The current investigation was envisaged to explore the responsiveness of oxidative stress parameters, DNA fragmentation and expression levels of TP53, cycloxygenase 2 COX2 and cytochrome p4502E1 CYP2E1 as toxicological endpoint in rats treated with DM. as well as attention was provided to the neuroprotective effect of vitamin E VE.

MethodsFour different groups of rats were used in this study, group I served as control, group II received DM 0.6 mg-kg BW, group III received both DM plus VE and finally group IV received VE only 200 mg-kg BW. The treatment regimen was extending for one month for all groups and the brain tissues were collected for further analysis.

ResultsThe obtained results showed a highly statistically significant increase in lipid peroxidation LPO content, nitric oxide concentration, and DNA fragmentation percentage and expression level of CYP2E1, TP53 and COX2 genes, in addition statistical significant reduction in total antioxidant capacity in DM treated group as compared to control were detected. Oral administration of VE attenuated the neurotoxic effects of DM through improvement of oxidative status, DNA fragmentation percentage and suppressing the expression level of CYP2E1, TP53 and COX2 genes.

ConclusionFrom this study we concluded that VE supplementation has beneficial impacts on DM neurotoxicity in rats through its antioxidant and antiapoptotic properties.

KeywordsDeltamethrin Brain Apoptosis Oxidative stress Vitamin E Electronic supplementary materialThe online version of this article doi:10.1186-1472-6882-14-458 contains supplementary material, which is available to authorized users.

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Author: Mona K Galal - Abdel Azim A Khalaf - Hanan A Ogaly - Marwa A Ibrahim

Source: https://link.springer.com/



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