Influence of acute hyperlipidemia to adipocyte-derived hormones in lean normotensive and subjects with metabolic syndromeReport as inadecuate

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Diabetology and Metabolic Syndrome

, 6:132

First Online: 02 December 2014Received: 19 May 2014Accepted: 20 November 2014


BackgroundAdipocyte-derived factors and regulators likely contribute to the metabolic syndrome MetS in patients with central obesity. This study was undertaken to assess the contribution of leptin, adiponectin, and acylation stimulating protein ASP-C3ades-ARG to hemodynamic blood pressure BP and metabolic insulin, glucose, lipids features of MetS.

MethodsIn this study, leptin, adiponectin, and C3ades-ARG were measured at baseline and in response to an infusion of Intralipid and heparin in 12 lean healthy controls and 12 patients with MetS.

ResultsBaseline plasma leptin 27.6 ± 6.2 vs. 10.9 ± 3.8 ng-mL, p < 0.01 and plasma C3ades-ARG 273 ± 79 vs 198 ± 57 mg-dL, p < 0.05 were higher in the MetS than control group, whereas baseline plasma adiponectin was higher in the control than MetS group 9.9 ± 1.9 vs. 5.4 ± 0.6 g-mL. Plasma leptin correlated with body mass index BMI, systolic and diastolic BP r = 0.53-0.77, p < 0.01. Conversely, adiponectin correlated inversely with insulin, glucose, waist circumference, and insulin sensitivity r = 0.48-0.51, p ≤ 0.02. Plasma triglycerides increased similarly in MetS and control groups after 4-hours of Intralipid and heparin. C3ades-ARG increased only in lean volunteers. The decrease in triglycerides 1-hour post-infusion was lower in the MetS than control group -116 ± 33 vs. -282 ± 81 mg-dL, p = 0.01 and correlated inversely with the change in C3ades-ARG.

ConclusionThese data suggest that leptin is more closely associated with hemodynamic BP aspects of MetS, whereas adiponectin and C3ades-ARG are more closely associated with metabolic components.

KeywordsIntralipid and heparin Adiponectin Leptin ASP-C3adesARG Lean normotensives Metabolic syndrome subjects AbbreviationsMetSMetabolic syndrome

ASP-C3ades-ARGAcylation stimulating protein

BPBlood pressure

BMIBody mass index

NEFAsNon-esterified fatty acids

FRAPFerric reducing activity of plasma

HOMAirHomeostatic model assessment for insulin sensitivity

GCRCGeneral Clinical Research Center.

Electronic supplementary materialThe online version of this article doi:10.1186-1758-5996-6-132 contains supplementary material, which is available to authorized users.

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Author: Heno F Lopes - Richard L Klein - W Timothy Garvey - Theodore Goodfriend - Brent M Egan



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