Triterpenoid resinous metabolites from the genus Boswellia: pharmacological activities and potential species-identifying propertiesReport as inadecuate




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Chemistry Central Journal

, 7:153

Biological Chemistry

Abstract

The resinous metabolites commonly known as frankincense or olibanum are produced by trees of the genus Boswellia and have attracted increasing popularity in Western countries in the last decade for their various pharmacological activities. This review described the pharmacological specific details mainly on anti-inflammatory, anti-carcinogenic, anti-bacterial and apoptosis-regulating activities of individual triterpenoid together with the relevant mechanism. In addition, species-characterizing triterpenic markers with the methods for their detection, bioavailability, safety and other significant properties were reviewed for further research.

Open image in new windowKeywordsBoswellia Triterpenoids Anti-inflammation Anti-carcinogenic Pharmacological activities Bioavailability Abbreviations5-LOX5-lipoxygenase

β-BAβ-Boswellic acid

Aβ-BA3-acetyl-β-BA

AKβ-BA3-acetyl-11-keto-β-BA

α-BAα-Boswellic acid

Aα-BA3-acetyl α-BA

BAsBoswellic acids

COXCyclooxygenase

CYPCytochrome P450

DRDeath receptor

EB-VEAEpstein–Barr virus early antigen

HKBAHexanoyloxy-11-keto-β-BA

HPLCHigh performanceliquid chromatography

IC50Ligand concentration that inhibits enzyme by 50%

IKKinhibitor of NF-κB kinase

Kβ-BA11-keto-β-BA

LPSLipopolysaccharide

MICMinimal inhibitory concentration

NF-κBNuclear factor-κB

NONitric oxide

NSAIDsNon-steroidal antiinflammatory drugs

PARPPoly-ADP-ribose polymerase

TLCThin-layer chromatography

TNFTumor necrosis factor

TPA12-O-tetradecanoylphorbol-13-acetate.

Electronic supplementary materialThe online version of this article doi:10.1186-1752-153X-7-153 contains supplementary material, which is available to authorized users.

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Author: Yuxin Zhang - Zhangchi Ning - Cheng Lu - Siyu Zhao - Jianfen Wang - Baoqin Liu - Xuegong Xu - Yuanyan Liu

Source: https://link.springer.com/







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