Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formationReport as inadecuate




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1 inconnu 2 CERMAV - Centre de recherches sur les macromolécules végétales

Abstract : Readily accessible, low-valency glycoclusters based on a triazine core bearing D-galactose and L-fucose epitopes are able to inhibit biofilm formation by Pseudomonas aeruginosa. These multivalent ligands are simple to synthesize, are highly soluble, and can be either homofunctional or heterofunctional. The galactose-decorated cluster shows good affinity for Pseudomonas aeruginosa lectin lecA. They are convenient biological probes for investigating the roles of lecA and lecB in biofilm formation.





Author: M. Smadhi - S. De Bentzmann - A. Imberty - M. Gingras - R. Abderrahim - P.G. Goekjian -

Source: https://hal.archives-ouvertes.fr/



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