Comparison of collision-induced dissociation and electron-induced dissociation of singly charged mononucleotidesReport as inadecuate




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1 IPCM - Institut Parisien de Chimie Moléculaire 2 COBRA - Chimie Organique et Bioorganique : Reactivité et Analyse

Abstract : The dissociation of singly charged mononucleotides by electron induced dissocn. EID and sustained off resonance irradiation-collision induced dissociation SORI-CID was investigated. The experiments have been carried out on deprotonated mononucleotides monomers. In general the same productions are observed in the EID and SORI-CID spectra but some additional productions have been obtained with EID. It was shown by MS3 experiments that all these addional productions have been produced through consecutive dissociations. of the M-2Hrad - radical anion. In addition, H-D exchange and sequential MS3 experiments demonstrated that the m-z 247 fragment ion produced in EID of deprotonated 2-deoxyguanosine 5-monophosphate corresponds to the association of the phosphate group and the nucleobase. They were most likely linked by a non-covalent bond that was initially present in the precursor ion.





Author: Viet Hung Nguyen - Carlos Afonso - Jean-Claude Tabet -

Source: https://hal.archives-ouvertes.fr/



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