The interplay between inflammation, physical activity and metabolic syndrome in a remote male geriatric community in Southern Taiwan: the Tianliao Old People TOP study 03Report as inadecuate




The interplay between inflammation, physical activity and metabolic syndrome in a remote male geriatric community in Southern Taiwan: the Tianliao Old People TOP study 03 - Download this document for free, or read online. Document in PDF available to download.

Diabetology and Metabolic Syndrome

, 5:60

First Online: 14 October 2013Received: 12 March 2013Accepted: 10 October 2013

Abstract

BackgroundBoth physical activity and inflammation are important in the pathophysiology of metabolic syndrome MetS. Our study aim is to explore their associations in an elderly male ≥ 65 years old cohort.

MethodsWe enrolled 309 elderly male residents mean age: 74.4 ± 6.0 years in a remote southern Taiwan community. The physical activity was recorded by a standard questionnaire. A high-sensitivity C-reactive protein hsCRP level > 3.0 mg-L indicated a high inflammatory status.

ResultsThe total prevalence rate of MetS was 27.8% in this male geriatric cohort. Median hsCRP levels were significantly higher in the MetS group 1.60 ± 0.7 vs. 1.0 ± 0.3 mg-L, p < 0.01, and the risk of elevated hsCRP increased with escalating MetS components p for trend < 0.001. The non-MetS group had higher amount of median weekly physical activity 183.1 ± 19.0 vs. 173.5 ± 10.6 MET-hr-week, p = 0.029, which was also higher among those with lower hsCRP levels 186.1 ± 14.1 vs. 167.8 ± 38.5 MET-hr-week, p = 0.013. Multivariate analysis showed that higher body mass index ORs: 1.527, 95% CI: 1.319-1.768, p < 0.01 insulin OR: 1.128, 95% CI: 1.045-1.218, p < 0.01 and physical activity ORs: 0.997, 95% IC: 0.994-0.999, p < 0.05 were independent predictors of MetS, but not hsCRP level p > 0.05.

ConclusionsReduced physical activity was one major pathophysiological MetS factor in our Asian geriatric participants.

KeywordsMetabolic syndrome Inflammation Physical activity Geriatric AbbreviationsMetSMetabolic syndrome

haCRPHigh-sensitivity C-reactive protein

ORsOdds ratios

DMDiabetes mellitus

IPAQInternational physical activity questionnaire

MET-hr-weekMetabolic equivalent task hours per week

NCEP-ATPIIINational cholesterol education program adult treatment panel III

HbA1CHemoglobin A1c

HDL-CHigh-density lipoprotein

LDL-CLow-density lipoprotein

BMIBody mass index

SDStandard deviation

SEStandard error

CIConfidence interval

TGTriglycerides

HTNHypertension

MetSCMetabolic syndrome component.

Electronic supplementary materialThe online version of this article doi:10.1186-1758-5996-5-60 contains supplementary material, which is available to authorized users.

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Author: Chia-Ling Chang - Po-Tseng Lee - Wei-Ting Chang - Chin-Sung Chang - Jyh-Hong Chen - Liang-Miin Tsai - Chih-Hsing Wu - Ping-

Source: https://link.springer.com/







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