Current evidence for the hepatoprotective activities of the medicinal mushroom Antrodia cinnamomeaReport as inadecuate

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Chinese Medicine

, 8:21

First Online: 01 November 2013Received: 08 May 2013Accepted: 23 October 2013


Antrodia cinnamomea AC is an endemic mushroom species of Taiwan, and has been demonstrated to possess diverse biological and pharmacological activities, such as anti-hypertension, anti-hyperlipidemia, anti-inflammation, anti-oxidation, anti-tumor, and immunomodulation. This review focuses on the inhibitory effects of AC on hepatitis, hepatocarcinoma, and alcohol-induced liver diseases e.g., fatty liver, fibrosis. The relevant biochemical and molecular mechanisms are addressed. Overall, this review summarizes the hepatoprotective activities in vitro and in vivo. However, there is no doubt that human and clinical trials are still limited, and further studies are required for the development of AC-related products.

AbbreviationsACAntrodia cinnamomea

FDAFood and Drug Administration

HAVHepatitis A virus

HBVHepatitis B virus

HCVHepatitis C virus

HDVHepatitis D virus

HCCHepatocellular carcinoma

HBsAgHepatitis B surface antigen

HBeAgHepatitis B e antigen


WHOWorld Health Organization

IARCInternational Agency for Research on Cancer

TNF-αTumor necrosis factor



VEGFVascular endothelial cell growth factor

FGF-2Fibroblast growth factor-2

ECEndothelial cell

VEGFR-1VEGF receptor 1

VEGFR-2VEGF receptor 2

MMPMatrix metalloproteinase

MAAMethyl antcinate A

MABMethyl antcinate B

TIMP-1Tissue inhibitor of metalloproteinases-1

TIMP-2Tissue inhibitor of metalloproteinases-2

ADHAlcohol dehydrogenase

H2O2Hydrogen peroxide

ALDHAldehyde dehydrogenase

ALDAlcoholic liver disease

ASTAspartate aminotransferase

ALTAlanine aminotransferase

ALPAlkaline phosphatase

CCl4Carbon tetrachloride


Nrf-2NF-E2 released factor

MAPKMitogen-activated protein kinase activation

ALDHAldehyde dehydrogenase.

Electronic supplementary materialThe online version of this article doi:10.1186-1749-8546-8-21 contains supplementary material, which is available to authorized users.

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Author: PatrickYing-Kit Yue - Yi-Yi Wong - KayYuen-Ki Wong - Yeuk-Ki Tsoi - KelvinSze-Yin Leung


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