Meta-analysis of acupuncture for relieving non-organic dyspeptic symptoms suggestive of diabetic gastroparesisReport as inadecuate




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BMC Complementary and Alternative Medicine

, 13:311

Clinical research

Abstract

BackgroundAcupuncture is widely used to treat diabetic patients with dyspeptic symptoms suggestive of gastroparesis in China. We conducted this systematic review of randomized controlled trials RCTs to evaluate the efficacy of acupuncture for diabetic gastroparesis DGP.

MethodsWe searched PubMed, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL and four Chinese databases including China National Knowledge Infrastructure CNKI, VIP Database for Chinese Technical Periodicals, Chinese Biomedical Literature Database CBM and WanFang Data up to January 2013 without language restriction. Eligible RCTs were designed to examine the efficacy of acupuncture in improving dyspeptic symptoms and gastric emptying in DGP. Risk of bias, study design and outcomes were extracted from trials. Relative risk RR was calculated for dichotomous data. Mean difference MD and standardized mean difference SMD were selected for continuous data to pool the overall effect.

ResultsWe searched 744 studies, among which 14 RCTs were considered eligible. Overall, acupuncture treatment had a higher response rate than controls RR, 1.20 95% confidence interval CI, 1.12 to 1.29, P < 0.00001, and significantly improved dyspeptic symptoms compared with the control group. There was no difference in solid gastric emptying between acupuncture and control. Acupuncture improved single dyspeptic symptom such as nausea and vomiting, loss of appetite and stomach fullness. However, most studies were in unclear and high risk of bias and with small sample size median = 62. The majority of the RCTs reported positive effect of acupuncture in improving dyspeptic symptoms.

ConclusionsThe results suggested that acupuncture might be effective to improve dyspeptic symptoms in DGP, while a definite conclusion about whether acupuncture was effective for DGP could not be drawn due to the low quality of trials and possibility of publication bias. Further large-scale, high-quality randomized clinical trials are needed to validate this claim and translate this result to clinical practice.

KeywordsAcupuncture Dyspeptic symptoms Diabetic gastroparesis Gastroprokinetic agent Meta-analysis Electronic supplementary materialThe online version of this article doi:10.1186-1472-6882-13-311 contains supplementary material, which is available to authorized users.

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Author: Mingxing Yang - Xiumin Li - Suhuan Liu - Zhipeng Li - Mei Xue - Dehong Gao - Xuejun Li - Shuyu Yang

Source: https://link.springer.com/







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