Temporal effect of HLA-B*57 on viral control during primary HIV-1 infectionReport as inadecuate




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Retrovirology

, 10:139

First Online: 18 November 2013Received: 20 August 2013Accepted: 28 October 2013

Abstract

BackgroundHLA-B alleles are associated with viral control in chronic HIV-1 infection, however, their role in primary HIV-1 disease is unclear. This study sought to determine the role of HLA-B alleles in viral control during the acute phase of HIV-1 infection and establishment of the early viral load set point VLSP.

FindingsIndividuals identified during primary HIV-1 infection were HLA class I typed and followed longitudinally. Associations between HLA-B alleles and HIV-1 viral replication during acute infection and VLSP were analyzed in untreated subjects. The results showed that neither HLA-B*57 nor HLA-B*27 were significantly associated with viral control during acute HIV-1 infection Fiebig stage I-IV, n=171. HLA-B*57 was however significantly associated with a subsequent lower VLSP p<0.001, n=135 with nearly 1 log10 less median viral load. Analysis of a known polymorphism at position 97 of HLA-B showed significant associations with both lower initial viral load p<0.01 and lower VLSP p<0.05. However, this association was dependent on different amino acids at this position for each endpoint.

ConclusionsThe effect of HLA-B*57 on viral control is more pronounced during the later stages of primary HIV-1 infection, which suggests the underlying mechanism of control occurs at a critical period in the first several months after HIV-1 acquisition. The risk profile of polymorphisms at position 97 of HLA-B are more broadly associated with HIV-1 viral load during primary infection and may serve as a focal point in further studies of HLA-B function.

KeywordsHLA-B*57 HLA-B Acute HIV-1 infection Primary HIV-1 infection Viral load set point MHC class I Electronic supplementary materialThe online version of this article doi:10.1186-1742-4690-10-139 contains supplementary material, which is available to authorized users.

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Author: Sagar A Vaidya - Hendrik Streeck - Noor Beckwith - Musie Ghebremichael - Florencia Pereyra - Douglas S Kwon - Marylyn M 

Source: https://link.springer.com/







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