Prognostic and predictive value of Phospho-p44-42 and pAKT in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapyReport as inadecuate




Prognostic and predictive value of Phospho-p44-42 and pAKT in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy - Download this document for free, or read online. Document in PDF available to download.

World Journal of Surgical Oncology

, 11:307

First Online: 30 November 2013Received: 23 April 2013Accepted: 09 November 2013

Abstract

BackgroundTo evaluate the predictive and prognostic value of various molecular factors associated with the Ras-MAPK and PI3K-Akt signaling pathways in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy NAC.

MethodsA total of 113 patients were recruited in this retrospective study. Core needle biopsies and excision samples were assessed through immunohistochemistry for various biomarkers, including IGF-1R, Phospho-p44-42, Ki67, pAKT, PTEN, p27, and cyclinD1. The changes in these biomarkers after NAC and their predictive and prognostic values were investigated.

ResultsSignificant decreases in Ki67, Phospho-p44-42, and pAKT expression were observed after treatment 30.7% vs. 18.1%, 36.4% vs. 18.9%, and 35.1% vs. 16.4%, respectively. The decreases in Phospho-p44-42, pAKT, and Ki67 expression were strongly associated with the response to anthracycline treatment P = 0.027, P = 0.031, and P = 0.008, respectively. In a multivariate survival analysis, Phospho-p44-42 expression after neoadjuvant chemotherapy and lymph node status were significant independent prognostic factors of both relapse-free survival and overall survival.

ConclusionsReductions in Ki-67, Phospho-p44-42, and pAKT expression are related to the clinical response to anthracycline-based NAC in HER2-positive breast cancer patients. High pAKT expression prior to NAC had a better clinical response. Phospho-p44-42 expression and lymph node status after NAC could be useful for determining relapse-free survival and overall survival.

KeywordsBreast cancer HER2-neu Neoadjuvant chemotherapy Overall survival pAKT Prognostic factors Phospho-p44-42 Relapse-free survival AbbreviationsERKExtracellular signal-related kinase

HER2Human epidermal growth factor Receptor 2

IGF-1RInsulin-like growth factor 1 receptor

MAPKMitogen-activated protein kinase

NACNeoadjuvant chemotherapy

pAKTPhospho-protein kinase B

Phospho-p44-42Phospho-mitogen-activated protein kinase

pMAPKPhosphorylated mitogen-activated protein kinase.

Electronic supplementary materialThe online version of this article doi:10.1186-1477-7819-11-307 contains supplementary material, which is available to authorized users.

Liang Huang, Tianwen Chen contributed equally to this work.

Download fulltext PDF



Author: Liang Huang - Tianwen Chen - Canming Chen - Sheng Chen - Yin Liu - Jiong Wu - Zhiming Shao

Source: https://link.springer.com/



DOWNLOAD PDF




Related documents