Elderly Patients with Diabetes Experience a Lower Rate of Nocturnal Hypoglycaemia with Insulin Degludec than with Insulin Glargine: A Meta-Analysis of Phase IIIa TrialsReport as inadecuate




Elderly Patients with Diabetes Experience a Lower Rate of Nocturnal Hypoglycaemia with Insulin Degludec than with Insulin Glargine: A Meta-Analysis of Phase IIIa Trials - Download this document for free, or read online. Document in PDF available to download.

Drugs and Aging

, Volume 30, Issue 12, pp 1009–1018

First Online: 30 October 2013

Abstract

Background and ObjectiveElderly patients with diabetes are more vulnerable to the occurrence and effects of hypoglycaemia; therefore, treatments with low risk of hypoglycaemia are preferred in this population. This study aimed to compare hypoglycaemia rates between insulin degludec IDeg and insulin glargine IGlar in elderly patients.

MethodsHypoglycaemia data from patients ≥65 years of age with type 1 T1DM or type 2 T2DM diabetes from seven randomised, treat-to-target phase IIIa trials were used to compare IDeg and IGlar in a pre-planned meta-analysis. Overall, 917-4345 21 % randomised patients in the seven trials were elderly 634 IDeg, 283 IGlar. Overall confirmed hypoglycaemia was defined as <3.1 mmol-L or severe hypoglycaemia symptoms requiring external assistance. Nocturnal hypoglycaemia included confirmed episodes from 0001 to 0559 hours inclusive. Treatment comparisons of hypoglycaemia in T1DM patients were not performed due to low numbers of elderly patients with T1DM randomised 43 IDeg, 18 IGlar; statistical comparisons were also not made for severe hypoglycaemia due to the low number of events.

ResultsIn elderly patients with T2DM, the rate of overall confirmed hypoglycaemia was significantly lower with IDeg than IGlar estimated rate ratio ERR 0.76 0.61; 0.9595 % CI; nocturnal confirmed hypoglycaemia was also significantly lower with IDeg ERR 0.64 0.43; 0.9595 % CI. Confirmed hypoglycaemia occurred in the majority of T1DM patients, whereas severe episodes occurred infrequently and at similar rates in both treatment groups in T1DM and T2DM.

ConclusionResults of this pre-planned meta-analysis in elderly patients with diabetes demonstrate a significant reduction in hypoglycaemic events with IDeg relative to IGlar.

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Author: Christopher Sorli - Mark Warren - David Oyer - Henriette Mersebach - Thue Johansen - Stephen C. L. Gough

Source: https://link.springer.com/



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