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Journal of Occupational Medicine and Toxicology

, 8:32

First Online: 11 December 2013Received: 26 August 2013Accepted: 29 November 2013

Abstract

Nanoparticles particles sized between 1 and 100 nanometers are more and more used in all fields of science and medicine for their physicochemical properties. As gold has traditionally been considered as chemically inert and biocompatible, in particular, gold nanoparticles have been established as valuable tools in several areas of biomedical research. But in contrast to the multitude of studies that addressed the clinical use of gold nanoparticles, only little is known about potential toxicological effects such as induction of inflammatory immune responses, possible apoptotic cell death or developmental growth inhibition in embryos. Therefore the present study performed a systematic review of toxicological data, especially experimentally acquired data concerning in-vivo-toxicity, published in the PubMed. It can be stated that the data in this area of research is still largely limited. Especially, knowledge about size-, charge- and surface-chemistry dependent in-vivo-toxicity is needed to predict the hazard potential of auric nanoparticles AuNPs for humans.

KeywordsGold Auric nanoparticles Toxicology In-vivo Electronic supplementary materialThe online version of this article doi:10.1186-1745-6673-8-32 contains supplementary material, which is available to authorized users.

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Author: Alexander Gerber - Matthias Bundschuh - Doris Klingelhofer - David A Groneberg

Source: https://link.springer.com/



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