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BMC Ophthalmology

, 13:78

Retina

Abstract

BackgroundThe association of inflammatory factors and the aqueous flare value with macular edema in central retinal vein occlusion CRVO patients remains unclear. We investigated the relations between the aqueous flare value and vitreous levels of vascular endothelial growth factor VEGF, soluble intercellular adhesion molecule-1 sICAM-1, and interleukin-6 IL-6 in patients with CRVO and macular edema or patients with idiopathic macular hole MH.

MethodsIn 38 patients who underwent unilateral vitrectomy 21 CRVO patients and 17 MH patients, vitreous samples were obtained during vitrectomy to measure VEGF, sICAM-1, and IL-6. Retinal ischemia was evaluated from capillary non-perfusion on fluorescein angiography, and the CRVO patients were classified into nonischemic or ischemic groups. Aqueous flare values were measured with a laser flare meter and macular edema was examined by optical coherence tomography.

ResultsThe median aqueous flare value increased significantly across the three groups MH group < nonischemic CRVO group < ischemic CRVO group. There was a significant correlation between the flare value and vitreous levels of VEGF, sICAM-1, and IL-6 in the CRVO group. The flare value was also significantly correlated with the severity of macular edema in the CRVO group.

ConclusionsInflammation and-or ischemia may increase vascular permeability and disrupt the blood-aqueous barrier by increasing levels of inflammatory factors in patients with CRVO and macular edema.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2415-13-78 contains supplementary material, which is available to authorized users.

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Author: Hidetaka Noma - Tatsuya Mimura - Maria Tatsugawa - Katsunori Shimada

Source: https://link.springer.com/



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